David Bowen Selected Research

Leukemia

2/2016

Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia.

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David Bowen Research Topics

Disease

23	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2021 - 01/2003
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2016 - 09/2003
3	Thrombocytopenia (Thrombopenia) 10/2020 - 01/2010
3	Fatigue 01/2020 - 02/2015
3	Anemia 01/2020 - 11/2005
3	Neoplasms (Cancer) 10/2015 - 09/2014
2	Nausea 01/2020 - 01/2016
2	Diarrhea 01/2020 - 01/2016
1	Body Weight (Weight, Body) 01/2020
1	Dizziness (Lightheadedness) 01/2020
1	Asthenia 01/2020
1	Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic) 01/2017
1	Leukemia 02/2016
1	Hematologic Neoplasms (Hematological Malignancy) 02/2016
1	Febrile Neutropenia 01/2016
1	Drug-Related Side Effects and Adverse Reactions 01/2016
1	Neutropenia 01/2016
1	Fever (Fevers) 01/2016
1	Alopecia (Baldness) 10/2015
1	Chronic Disease (Chronic Diseases) 02/2015
1	Chromosome Aberrations (Chromosome Abnormalities) 09/2014
1	Primary Myelofibrosis (Myelosclerosis) 10/2013
1	Splenomegaly 10/2013
1	Hemorrhage 01/2010
1	Bone Marrow Failure Disorders 11/2009
1	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 11/2009
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 05/2008
1	Mitochondrial Diseases (Mitochondrial Disease) 05/2008
1	Refractory Anemia 04/2008
1	sideroblastic spinocerebellar ataxia Anemia 04/2008
1	Disease Progression 06/2002
1	Refractory Anemia with Excess of Blasts (RAEM) 06/2002
1	Necrosis 06/2002

Drug/Important Bio-Agent (IBA)

6	IronIBA 01/2021 - 04/2008
2	Arsenic Trioxide (Trisenox)FDA Link 10/2015 - 06/2006
2	Lenalidomide (CC 5013)FDA Link 11/2014 - 10/2011
1	Deferasirox FDA Link 01/2020
1	HematinicsIBA 01/2020
1	luspaterceptIBA 01/2020
1	Transferrin Receptors (Transferrin Receptor)IBA 01/2018
1	Transferrin (beta 2 Transferrin)IBA 01/2018
1	Growth Differentiation Factor 15IBA 01/2018
1	RG7112IBA 02/2016
1	Decitabine FDA Link 01/2016
1	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 10/2015
1	Alanine Transaminase (SGPT)IBA 10/2015
1	MDS 004IBA 11/2014
1	Proteins (Proteins, Gene)FDA Link 06/2014
1	Biological ProductsIBA 11/2013
1	Janus Kinase InhibitorsIBA 10/2013
1	ruxolitinibIBA 10/2013
1	Cytarabine (Cytosar-U)FDA LinkGeneric 08/2013
1	NucleosidesIBA 08/2013
1	Clofarabine (Clolar)FDA Link 08/2013
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 09/2012
1	Ferritins (Ferritin)IBA 09/2012
1	Pharmaceutical PreparationsIBA 11/2010
1	Azacitidine (5 Azacytidine)FDA Link 11/2010
1	romiplostim FDA Link 01/2010
1	Telomerase (Telomerase Reverse Transcriptase)IBA 11/2009
1	Mitochondrial DNA (mtDNA)IBA 05/2008
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 04/2008
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 05/2006
1	Erythropoietin FDA Link 05/2006
1	AntioxidantsIBA 09/2003
1	EnzymesIBA 09/2003
1	Interleukin-10 (Interleukin 10)IBA 06/2002
1	CytokinesIBA 06/2002
1	AntigensIBA 06/2002
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2002
1	DNA (Deoxyribonucleic Acid)IBA 06/2002
1	RA 25IBA 06/2002
1	Lymphotoxin-alpha (Lymphotoxin)IBA 06/2002

Therapy/Procedure

6	Therapeutics 01/2020 - 01/2003
3	Erythrocyte Transfusion 01/2020 - 11/2015
3	Drug Therapy (Chemotherapy) 09/2014 - 11/2005
2	Platelet Transfusion (Blood Platelet Transfusions) 10/2020 - 01/2010
1	Chelation Therapy (Therapy, Chelation) 01/2020
1	Hematopoietic Stem Cell Transplantation 01/2017
1	Transplantation 01/2017
1	Induction Chemotherapy 01/2016
1	Remission Induction 09/2014